The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

The skin barrier would not function without IL-1 family members, but their physiological role
in the immunological aspects of skin barrier function are often overlooked. This review …

Adult-onset Still's disease (AoSD) is a rare systemic autoinflammatory disease characterized
by arthritis, spiking fever, skin rash and elevated ferritin levels. The reason behind the …

The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is
positioned at the “epicenter” of the inflammatory signaling networks. Increased levels of the …

Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …

The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Blockade of the interleukin-1 (IL-1) pathway has been used therapeutically in several
inflammatory diseases including arthritis and cryopyrin-associated periodic syndrome …

Autoinflammatory diseases are disorders of the innate immune system, which can be either
monogenic due to a specific genetic mutation or complex multigenic due to the involvement …

Abstract Background Adult-onset Still's disease (AOSD) is a rare inflammatory disease,
typically characterized by spiking fever, skin rash, and arthralgia or arthritis. Its conventional …