The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis
and integrity through the control of paracellular permeability and cell polarity. Recent …

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

The epithelial-mesenchymal transition (EMT) is an essential step in cancer progression.
Epithelial cells possess several types of cell-cell junctions, and tight junctions are known to …

The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …

Claudins are major integral membrane proteins of tight junctions. Altered expression of
several claudin proteins, in particular claudin-1,-3,-4 and-7, has been linked to the …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-
selective and water permeable paracellular channels. Its abundance is under fine control by …