Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them
toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex …

A major contributing factor to glioma development and progression is its ability to evade the
immune system. This chapter will explore the mechanisms utilized by glioma to mediate …

The up-regulation of cyclooxygenase 2 (COX-2) expression is a frequent occurrence in a
variety of different tumors. In this study, COX-2 protein expression was investigated in 50 …

As the inducible terminal enzyme for prostaglandin E2 (PGE 2) synthesis, microsomal PGE
synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after …

It is well established that traditional NSAIDs, which inhibit cyclooxygenase (COX) 1 and COX-
2, have the potential to reduce the risk of colorectal cancer. New generation COX inhibitors …

Eicosanoids constitute a large family of biologically active lipid mediators that are produced
by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12 …

Abstract Prostaglandin E2 (PGE2) has been shown to play important roles in several
aspects of tumor development and progression. PGE2 is synthesized from arachidonic acid …

Recognition of two isoforms of cyclooxygenase and reports that nonsteroidal anti-
inflammatory drugs may be beneficial in devastating neurological conditions such as …

Opinion statement Medulloblastoma (MB) is the most common pediatric brain malignancy,
with a 5-year overall survival (OS) rate of around 65%. The conventional MB treatment …

✓ Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors
(coxibs), because this particular compound exerts a second function that is independent of …