Heart regeneration, a relatively new field of biology, is one of the most active and
controversial areas of biomedical research. The potential impact of successful human heart …

Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell
states stabilized with different culture conditions. Their distinct spatiotemporal characteristics …

Heart attack is a global health problem that leads to significant morbidity, mortality, and
health care burden. Adult human hearts have very limited regenerative capability after injury …

Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …

Background—Adult mammalian cardiomyocytes (CMs) have the potential to proliferate, but
this is not sufficient to generate adequate CMs after myocardial infarction (MI). The …