This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Chronic kidney disease (CKD) is a progressive systemic disease, which changes the
function and structure of the kidneys irreversibly over months or years. The final common …

Vascular remodeling is a common pathological hallmark of many cardiovascular diseases.
Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media …

Alterations in the vascular smooth muscle cells (VSMC) phenotype play a critical role in the
pathogenesis of several cardiovascular diseases, including hypertension, atherosclerosis …

Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

Elevated large-artery stiffness is recognized as an independent predictor of cardiovascular
and all-cause mortality. The mechanisms responsible for such stiffening are incompletely …

BACKGROUND: Inflammation plays a critical role in the development of hypertension and
vascular remodeling. Resolvin E1 (RvE1), as one of the specialized proresolving lipid …