Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Alpha 2-Heremans-Schmid glycoprotein, also known as fetuin-A (Fet-A), is a multifunctional
plasma glycoprotein that has been identified in both animal and human beings. The protein …

The COVID-19 global pandemic is an international health emergency. It is caused by the
SARS-CoV-2 virus, which binds with its trimeric Spike protein to the ACE2 receptor in the …

Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the
ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic …

Abstract Knowledge of molecular weight, oligomeric states, and quaternary arrangements of
proteins in solution is fundamental for understanding their molecular functions and activities …

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the
pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) …

Many viral surface glycoproteins and cell surface receptors are homo-oligomers,,,, and thus
can potentially be targeted by geometrically matched homo-oligomers that engage all …

Abstract Structure-based design of vaccines, particularly the iterative optimization used so
successfully in the structure-based design of drugs, has been a long-sought goal. We …

Wnt signalling regulates multiple processes including angiogenesis, inflammation, and
tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although …

The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as
the “glycan shield,” is a key determinant of immunogenicity, yet intrinsic heterogeneity …