Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the
expression of inflammatory molecules, including other cytokines and cell adhesion …

Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …

Co-inhibitory receptors are important regulators of T-cell function that define the balance
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Antiphospholipid syndrome is an autoimmune disorder characterized by vascular
thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody …

Cytokine release syndrome (CRS) embodies a mixture of clinical manifestations, including
elevated circulating cytokine levels, acute systemic inflammatory symptoms and secondary …

There is an emerging interest in applying inorganic and organometallic transition metal
complexes to biomolecular and cellular studies. The cytotoxic effects of these complexes on …

Autoinflammatory disorders and autoimmune diseases result from abnormal deviations of
innate and adaptive immunity that heterogeneously affect organs and clinical phenotypes …

Tumor necrosis factor-a (TNF-a) is a pro-inflammatory cytokine that plays a critical role in key
biological processes, including haematopoiesis, immunity, and inflammation.[1] Aberrant …