Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but
underlying mechanisms are not understood. Analyses of 700 human blood transcriptomes …

Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is
fundamental to developmental biology, organ physiology, and immunology. Macrophages …

The mitochondrial calcium uniporter, which regulates aerobic metabolism by catalyzing
mitochondrial Ca2+ influx, is arguably the most selective ion channel known. The …

Recognition of pathogen-associated molecular patterns can trigger the inositol-requiring
enzyme 1 α (IRE1α) arm of the endoplasmic reticulum (ER) stress response in innate …

Ability to stimulate antimicrobial immunity has proven to be a useful therapeutic strategy in
treating infections, especially in the face of increasing antibiotic resistance. Natural …

Abstract T-cell receptor (TCR)-induced Ca2+ signals are essential for T-cell activation and
function. In this context, mitochondria play an important role and take up Ca2+ to support …

Abstract Platelet‐activating factor (PAF, 1‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine)
was discovered when the mechanisms involved in the deposition of immune complex in …

Solute carrier (SLC) transporters are membrane-bound proteins that facilitate nutrient
transport, and the movement across cellular membranes of various substrates ranging from …

T cell activation and differentiation is associated with metabolic reprogramming to cope with
the increased bioenergetic demand and to provide metabolic intermediates for the …

Monocyte-derived dendritic cells (MDDCs) are key players in the defense against fungal
infection because of their outstanding capacity for non-opsonic phagocytosis and …