Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later

AM Ryan, DG Power, L Daly, SJ Cushen… - Proceedings of the …, 2016 - cambridge.org
An awareness of the importance of nutritional status in hospital settings began more than 40
years ago. Much has been learned since and has altered care. For the past 40 years several …

Diagnostic criteria for the classification of cancer-associated weight loss

L Martin, P Senesse, I Gioulbasanis… - Journal of clinical …, 2015 - ascopubs.org
Purpose Existing definitions of clinically important weight loss (WL) in patients with cancer
are unclear and heterogeneous and do not consider current trends toward obesity. Methods …

Cachexia in patients with oesophageal cancer

P Anandavadivelan, P Lagergren - Nature reviews Clinical oncology, 2016 - nature.com
Oesophageal cancer is a debilitating disease with a poor prognosis, and weight loss owing
to malnutrition prevails in the majority of patients. Cachexia, a multifactorial syndrome …

Cancer and inflammation: an old intuition with rapidly evolving new concepts

G Trinchieri - Annual review of immunology, 2012 - annualreviews.org
Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

[HTML][HTML] Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force

M Aapro, J Arends, F Bozzetti, K Fearon… - Annals of …, 2014 - Elsevier
Background Weight loss and cachexia are common, reduce tolerance of cancer treatment
and the likelihood of response, and independently predict poor outcome. Methods A group …

[HTML][HTML] Cancer cachexia, mechanism and treatment

T Aoyagi, KP Terracina, A Raza… - World journal of …, 2015 - ncbi.nlm.nih.gov
It is estimated that half of all patients with cancer eventually develop a syndrome of
cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass …

Cancer cachexia—pathophysiology and management

H Suzuki, A Asakawa, H Amitani, N Nakamura… - Journal of …, 2013 - Springer
About half of all cancer patients show a syndrome of cachexia, characterized by anorexia
and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact …

Energy metabolism in cachexia

M Rohm, A Zeigerer, J Machado, S Herzig - EMBO reports, 2019 - embopress.org
Cachexia is a wasting disorder that accompanies many chronic diseases including cancer
and results from an imbalance of energy requirements and energy uptake. In cancer …

Cancer cachexia: mechanisms and clinical implications

CL Donohoe, AM Ryan… - … research and practice, 2011 - Wiley Online Library
Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting
in progressive weight loss. It is associated with poor quality of life, poor physical function …