Purpose To review pharmacokinetic and pharmacodynamic characteristics of antibodies that
bind to soluble ligands within the framework of calcitonin gene-related peptide antibodies …

EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …

Aims The development of monoclonal antibodies (mAbs) requires an understanding of the
interindividual variability (IIV) in pharmacokinetics (PK) at the population level facilitated by …

Therapeutic antibodies are increasingly used to treat various diseases, including neoplasms
and chronic inflammatory diseases. Antibodies exhibit complex pharmacokinetic properties …

Background Migraine clinical profile may change with age, making it necessary to verify that
migraine treatments are equally safe and effective in older patients. These analyses …

Background: Compared with anti-infective drugs, immunosuppressants and other fields, the
application of therapeutic drug monitoring (TDM) in oncology is somewhat limited. Objective …

Cancer immunotherapy has appeared as a prospective therapeutic modality. Therapeutic
antibodies induced in an in vitro expression system act as “targeting missiles” against tumor …

作为非小细胞肺癌(non-small cell lung cancer, NSCLC) 中重要的致癌驱动基因,
表皮生长因子受体外显子20 插入突变(epidermal growth factor receptor exon 20 insertion …

We sought to describe the exposure–response relationship of necitumumab efficacy in
squamous non‐small cell lung cancer patients and evaluate intrinsic and extrinsic patient …

作为非小细胞肺癌 (non-small cell lung cancer, NSCLC) 中重要的致癌驱动基因,
表皮生长因子受体外显子 20 插入突变 (epidermal growth factor receptor exon 20 insertion …