Targeting inflammation to treat diabetic kidney disease: the road to 2030

S Rayego-Mateos, RR Rodrigues-Diez… - Kidney international, 2023 - Elsevier
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Y Shi, Y Wang, Q Li, K Liu, J Hou, C Shao… - Nature Reviews …, 2018 - nature.com
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …

Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury

L Li, Y Zhang, J Mu, J Chen, C Zhang, H Cao, J Gao - Nano letters, 2020 - ACS Publications
Spinal cord injury is among the most fatal diseases. The complicated inhibitory
microenvironment requires comprehensive mitigation. Exosomes derived from …

Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications

D Tsiapalis, L O'Driscoll - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment

WS Toh, RC Lai, JHP Hui, SK Lim - Seminars in cell & developmental …, 2017 - Elsevier
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …

Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target

J Chen, Q Liu, J He, Y Li - Frontiers in Immunology, 2022 - frontiersin.org
Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents

V Börger, M Bremer, R Ferrer-Tur, L Gockeln… - International journal of …, 2017 - mdpi.com
Extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as
mediators of a newly-discovered intercellular communication system. They are essential …

Trophic effects of mesenchymal stem cells in tissue regeneration

Y Fu, L Karbaat, L Wu, J Leijten, SK Both… - … Engineering Part B …, 2017 - liebertpub.com
Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-
based therapy and for tissue regeneration in particular. Recent evidence indicates that the …

Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway

N Ebrahim, IA Ahmed, NI Hussien, AA Dessouky… - Cells, 2018 - mdpi.com
Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and a
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …

Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy

C Grange, S Tritta, M Tapparo, M Cedrino, C Tetta… - Scientific reports, 2019 - nature.com
Extracellular vesicles (EVs) that are derived from mesenchymal stromal cells (MSCs) have
been shown to reprogram injured cells by activating regenerative processes. We herein …