Updates on mouse models of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …
States (US). Animal models, specifically mouse models have been developed to better …
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
J Homolak - Advances in Protein Chemistry and Structural Biology, 2023 - Elsevier
Neurodegenerative diseases are a group of age-related disorders characterized by a
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …
Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose …
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …
Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic
tone, and homeostasis. Tau‐associated NSS degeneration occurs early in Alzheimer's …
tone, and homeostasis. Tau‐associated NSS degeneration occurs early in Alzheimer's …
Insulin and α-tocopherol enhance the protective effect of each other on brain cortical neurons under oxidative stress conditions and in rat two-vessel forebrain …
IO Zakharova, LV Bayunova, II Zorina… - International Journal of …, 2021 - mdpi.com
Clinical trials show that insulin administered intranasally is a promising drug to treat
neurodegenerative diseases, but at high doses its use may result in cerebral insulin …
neurodegenerative diseases, but at high doses its use may result in cerebral insulin …
Combined analysis of single-cell and bulk RNA sequencing reveals the expression patterns of circadian rhythm disruption in the immune microenvironment of …
H He, Y Yang, L Wang, Z Guo, L Ye… - Frontiers in …, 2023 - frontiersin.org
Background Circadian rhythm disruption (CRD) represents a critical contributor to the
pathogenesis of Alzheimer's disease (AD). Nonetheless, how CRD functions within the AD …
pathogenesis of Alzheimer's disease (AD). Nonetheless, how CRD functions within the AD …
[HTML][HTML] Light-eye-body axis: exploring the network from retinal illumination to systemic regulation
Y Zeng, R Rong, M You, P Zhu, J Zhang, X Xia - Theranostics, 2025 - pmc.ncbi.nlm.nih.gov
The human body is an intricate system, where diverse and complex signaling among
different organs sustains physiological activities. The eye, as a primary organ for information …
different organs sustains physiological activities. The eye, as a primary organ for information …
Simultaneous alteration of the circadian variation of memory, hippocampal synaptic plasticity, and metabolism in a triple transgenic mouse model of Alzheimer's …
AM Carvalho da Silva, C Lemos, HB Silva… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by
synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a …
synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a …
Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular …
A Matynia, BS Recio, Z Myers, S Parikh… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in
non–image-forming visual functions. Given their significant loss observed in various ocular …
non–image-forming visual functions. Given their significant loss observed in various ocular …
Patofiziološke promjene probavnog sustava u životinjskim modelima Alzheimerove i Parkinsonove bolesti
J Homolak - 2023 - repozitorij.mef.unizg.hr
Alzheimerova (AB) i Parkinsonova bolest (PB) najučestalije su neurodegenerativne bolesti s
nerazjašnjenom etiopatogenezom, a istraživanja upućuju na važnu ulogu probavnog …
nerazjašnjenom etiopatogenezom, a istraživanja upućuju na važnu ulogu probavnog …