Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …

Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus that
infected more than 8000 individuals and resulted in more than 800 (10–15%) fatalities in …

The novel coronavirus, SARS-CoV-2, has been identified as the causative agent for the
current coronavirus disease (COVID-19) pandemic. 3CL protease (3CLpro) plays a pivotal …

This review fully describes the coronavirus 3CL pro peptidomimetic inhibitors and
nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the …

The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …

Highlights•The main protease, known as M pro, is encoded by the viral genome and is
essential for viral replication.•The effective target for drug development has been the M …

Trimethylsilyl nucleophiles (Me3SiNu), with silicon atoms attached to carbon, nitrogen,
oxygen, or sulfur atoms, have long been recognized as effective alternatives for proton …

The emerging COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has raised a global catastrophe. To date, there is no specific …

Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still
spreading at an alarming rate and has caused huge loss of life and economic damage …

Because of its impressive ability to promote pharmaceutical activity, the introduction of
trifluoromethylacyl (CF3CO) functionality into organic compounds has become an important …