Anti-tumor necrosis factor (TNF) antibodies are successfully used in the therapy of
inflammatory bowel diseases (IBD). However, the molecular mechanism of action of these …

Tumor necrosis factor (TNF) is a pleiotropic cytokine powerfully influencing diverse
processes of the central nervous system (CNS) under both physiological and pathological …

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly
by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory cytokine exerting pleiotropic
effects on various cell types. It is synthesized in a precursor form called transmembrane TNF …

Bergenin (BG) is a polyphenolic substance which has therapeutic potential in the treatment
of diabetic nephropathy (DN), a common complication of type II diabetes. However, the …

ABSTRACT TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein,
anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to …

Background and aim Luteolin belongs to flavone group of flavonoids, present in many plants
with potent antioxidant, anti-inflammatory and anti-proliferative effects. The objective of …

Viral causes of pneumonia pose constant threats to global public health, but there are no
specific treatments currently available for the condition. Antivirals are ineffective when …

Monocyte-derived macrophages are readily differentiating cells that adapt their gene
expression profile to environmental cues and functional needs. During the resolution of …

Mesenchymal stem cells (MSCs) have been broadly used as a therapy for autoimmune
disease in both animal models and clinical trials. MSCs inhibit T effector cells and many …