The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

RNA decay plays a major role in regulating gene expression and is tightly networked with
other aspects of gene expression to effectively coordinate post-transcriptional regulation …

Along with a growing interest in mRNA-based gene therapies, efforts are increasingly
focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo …

Removal of the 5′ cap on mRNA by the decapping enzyme Dcp2 is a critical step in 5′-to-
3′ mRNA decay. Understanding the structural basis of Dcp2 activity has been a challenge …

The cap is a natural modification present at the 5'ends of eukaryotic messenger RNA
(mRNA), which because of its unique structural features, mediates essential biological …

The conserved decapping enzyme Dcp2 recognizes and removes the 5′ eukaryotic cap
from mRNA transcripts in a critical step of many cellular RNA decay pathways. Dcp2 is a …

In eukaryotes, the elimination of the m7GpppN mRNA cap, a process known as decapping,
is a critical, largely irreversible and highly regulated step of mRNA decay that withdraws the …

DCP2 is an RNA-decapping enzyme that controls the stability of human RNAs that encode
factors functioning in transcription and the immune response. While> 1,800 human DCP2 …

The stability of RNAs represents a crucial point for cell life in that these molecules code for
proteins and also play structural and regulatory functions. In this review, we will mainly focus …

Vaccinia virus (VACV) represents a family of poxviruses, which possess their own
decapping machinery as a part of their strategy to eliminate host mRNAs and evade the …