Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Cancer stem cell hierarchy in glioblastoma multiforme

A Bradshaw, A Wickremsekera, ST Tan, L Peng… - Frontiers in …, 2016 - frontiersin.org
Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

AA Ren, DA Snellings, YS Su, CC Hong, M Castro… - Nature, 2021 - nature.com
Vascular malformations are thought to be monogenic disorders that result in dysregulated
growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing …

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

LS Shankman, D Gomez, OA Cherepanova… - Nature medicine, 2015 - nature.com
Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in
the pathogenesis of atherosclerosis have provided controversial results owing to the use of …

Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel-like factors in cancer

MP Tetreault, Y Yang, JP Katz - Nature Reviews Cancer, 2013 - nature.com
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

K Kaji, K Norrby, A Paca, M Mileikovsky, P Mohseni… - Nature, 2009 - nature.com
Reprogramming of somatic cells to pluripotency, thereby creating induced pluripotent stem
(iPS) cells, promises to transform regenerative medicine. Most instances of direct …

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

F Yu, J Li, H Chen, J Fu, S Ray, S Huang, H Zheng… - Oncogene, 2011 - nature.com
Abstract Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers
and functions as an oncogene. However, an exact mechanism by which KLF4 enhances …

A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog

JK Ichida, J Blanchard, K Lam, EY Son, JE Chung… - Cell stem cell, 2009 - cell.com
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

K Yusa, R Rad, J Takeda, A Bradley - Nature methods, 2009 - nature.com
Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by
transgenic expression of Oct4 (Pou5f1), Sox2, Klf4 and Myc. A major difficulty in the …