Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Glutamine utilization promotes enhanced growth of cancer cells. We propose a new concept
map of cancer metabolism in which mitochondrial NADH and NADPH, in the presence of a …

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism
of glucose to lactate. It remains unknown what quantitative changes to the activity of …

Quantitative and qualitative knowledge of metabolic rates (ie fluxes) over a metabolic
network and in specific cellular compartments gives insights into the regulation of …

The human gut microbiota performs essential functions for host and well‐being, but has also
been linked to a variety of disease states, eg, obesity and type 2 diabetes. The mammalian …

Cancer metabolism has received renewed interest as a potential target for cancer therapy. In
this study, we use a multi-scale modeling approach to interrogate the implications of three …

The Warburg effect, or aerobic glycolysis, is marked by the increased metabolism of glucose
to lactate in the presence of oxygen. Despite its widespread prevalence in physiology and …

Abstract The Nobel Prize Winner (1931) Dr. Otto H. Warburg had established that the
primary energy source of the cancer cell is aerobic glycolysis (the Warburg effect). He also …

A network model for the determination of tumor metabolic fluxes from 13 C NMR kinetic
isotopomer data has been developed and validated with perfused human DB-1 melanoma …

We present the first validated metabolic network model for analysis of flux through key
pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non …