W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …
Z Wei, X Zhang, T Yong, N Bie, G Zhan, X Li… - Nature …, 2021 - nature.com
The main challenges for programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …
Localized or topical administration of drugs may be considered as a potential approach for overcoming the problems caused by the various biological barriers encountered in drug …
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution in the pharmaceutical industry because they can be used for precise and individualized …
X Liu, P Huang, R Yang, H Deng - ACS nano, 2023 - ACS Publications
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA vaccine for the prevention of COVID-19, which has pushed this field to be more closely …
X Qu, D Zhou, J Lu, D Qin, J Zhou, HJ Liu - Bioactive materials, 2023 - Elsevier
Surgical resection remains a mainstay in the treatment of malignant solid tumors. However, the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …
Abstract mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …
W Gu, F Meng, R Haag, Z Zhong - Journal of controlled release, 2021 - Elsevier
The development of targeted nanomedicines for cancer therapy has been an utmost focus of research across different fields including materials science, nanotechnology, biotechnology …