mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Polymer‐based mRNA delivery strategies for advanced therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

Z Wei, X Zhang, T Yong, N Bie, G Zhan, X Li… - Nature …, 2021 - nature.com
The main challenges for programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) checkpoint
blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …

Overcoming barriers by local drug delivery with liposomes

SG Antimisiaris, A Marazioti, M Kannavou… - Advanced drug delivery …, 2021 - Elsevier
Localized or topical administration of drugs may be considered as a potential approach for
overcoming the problems caused by the various biological barriers encountered in drug …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

The challenge and prospect of mRNA therapeutics landscape

Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

mRNA Cancer vaccines: construction and boosting strategies

X Liu, P Huang, R Yang, H Deng - ACS nano, 2023 - ACS Publications
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

[HTML][HTML] Cancer nanomedicine in preoperative therapeutics: Nanotechnology-enabled neoadjuvant chemotherapy, radiotherapy, immunotherapy, and phototherapy

X Qu, D Zhou, J Lu, D Qin, J Zhou, HJ Liu - Bioactive materials, 2023 - Elsevier
Surgical resection remains a mainstay in the treatment of malignant solid tumors. However,
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …

mRNA vaccine for cancer immunotherapy

L Miao, Y Zhang, L Huang - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have become a promising platform for cancer immunotherapy.
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …

Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation

W Gu, F Meng, R Haag, Z Zhong - Journal of controlled release, 2021 - Elsevier
The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …