Muscarinic acetylcholine receptors belong to the G protein-coupled receptor superfamily
and are widely known to mediate numerous functions within the central and peripheral …

Despite a reduction in incidence over the past decade, colon cancer remains the second
most common cause of cancer death in the United States; recent demographics suggest this …

Forbidden in some countries due to its proven toxicity to humans, chlorpyrifos (CPF) still
stands as an organophosphate pesticide (OP) highly used worldwide. Cardiotoxicity …

Background We previously established that the non-neuronal cardiac cholinergic system
(NNCCS) is equipped with cardiomyocytes synthesizes acetylcholine (ACh), which is an …

As an indispensable component in human beings, the acetylcholine system regulates
multiple physiological processes not only in neuronal tissues but also in nonneuronal …

Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a
significant role in the current pharmacology. Besides the pharmacological importance, they …

Since the discovery of non-neuronal acetylcholine in the heart, this specific system has
drawn scientific interest from many research fields, including cardiology, immunology, and …

Acetylcholine (ACh) is found not only in cholinergic nerve termini but also in the
nonneuronal cholinergic system (NNCS). ACh is released from cholinergic nerves by …

The role and outcome of the muscarinic M2 acetylcholine receptor (M2R) signaling in
healthy and diseased cardiomyocytes is still a matter of debate. Here, we report that the long …

Previous studies have suggested that the Angiotensin-(1− 7)[(Ang-(1− 7)] can change
cardiac function by modulating the autonomic nervous system. However, it is unknown …