Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes

A Farina, M Villagrán-García, A Vogrig… - The Lancet …, 2024 - thelancet.com
Immune checkpoint inhibitors, a class of oncological treatments that enhance antitumour
immunity, can trigger neurological adverse events closely resembling paraneoplastic …

[HTML][HTML] Soluble biomarkers for immune checkpoint inhibitor-related encephalitis: A mini-review

A Farina, M Villagrán-García, B Joubert - Revue Neurologique, 2024 - Elsevier
Immune checkpoint inhibitors lead to effective antitumour responses but also to immune-
related adverse events (irAEs), which affect the nervous system in 1–5% of patients …

[HTML][HTML] AI and Deep Learning in Understanding the Etiology and Pathogenesis of Autoimmune Diseases

A Rigi, K Harati, M Abbaspour, SF Fattahpour… - Kindle, 2024 - preferpub.org
Autoimmune diseases arise when the immune system mistakenly attacks the body's own
tissues, leading to chronic inflammation and organ damage. These disorders are complex …

Diagnostic and prognostic biomarkers in immune checkpoint inhibitor-related encephalitis: a retrospective cohort study

A Farina, M Villagrán-García, A Fourier… - The Lancet Regional …, 2024 - thelancet.com
Background Immune checkpoint inhibitor-related encephalitis (ICI-encephalitis) is not well
characterised and diagnostic and prognostic biomarkers are lacking. We aimed to …

Clinical course of neurologic adverse events associated with immune checkpoint inhibitors: focus on chronic toxicities

S Rossi, A Farina, A Malvaso, A Dinoto… - Neurology …, 2024 - neurology.org
Background and Objectives The clinical course and the risk of chronicity of neurologic
immune-related adverse events (n-irAEs) associated with immune checkpoint inhibitors …

Prognostic relevance of immune-related adverse events in lung cancer patients undergoing immune checkpoint inhibitor therapy: a systematic review and meta …

Y Huang, W Ma, D Wu, M Lyu, Q Zheng… - Translational Lung …, 2024 - pmc.ncbi.nlm.nih.gov
Background Immune checkpoint inhibitors (ICIs) work by activating the immune system, a
mechanism that may also cause immune-related adverse events (irAEs). This study seeks to …

Central nervous system adverse events of immune checkpoint inhibitors

A Farina, M Villagrán-García, A Vogrig… - Current Opinion in …, 2024 - journals.lww.com
The clinical and outcomes diversity of CNS-irAEs suggests different pathogenic
mechanisms, which need to be understood to establish more effective and specific treatment …

Predicting the future of autoimmune encephalitides

M Guasp, J Dalmau - Revue Neurologique, 2024 - Elsevier
The concept that many neurologic and psychiatric disorders of unknown cause are immune-
mediated has evolved fast during the past 20 years. The main contribution to the expansion …

Central nervous system manifestations in acute and chronic graft-versus-host disease

N Lambert, F Forte, M El Moussaoui, J Monseur… - Brain, 2024 - academic.oup.com
Despite the growing evidence supporting the existence of CNS involvement in acute and
chronic graft-versus-host disease (CNS-GvHD), the characteristics and course of the …

Fluorinated Chitosan‐Mediated Transepithelial Delivery of Intravesical Dual‐Drug Immunotherapeutic for Bladder Cancer Therapy

L Feng, G Huang, Q Lei, M Liang, D Deng… - Advanced …, 2024 - Wiley Online Library
Intravesical instillation‐based immunotherapy for bladder‐preservation of bladder cancer
(BCa) treatment has not been explored. In the current study, two irrigated nano‐formulations …