Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Abstract Purpose of Review Full and partial synthetic agonists targeting the transcription
factor PPARγ are contained in FDA-approved insulin-sensitizing drugs and used for the …

Activated by retinoids, metabolites of vitamin A, the retinoic acid receptors (RARs) and the
retinoid X receptors (RXRs) play important roles in a wide variety of biological processes …

Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization
with other nuclear hormone receptors (NRs), contributing thereby to activities of different …

Nuclear receptor (NR) transcription factors use a conserved activation function-2 (AF-2) helix
12 mechanism for agonist-induced coactivator interaction and NR transcriptional activation …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an
overall survival of 5% at five years. The development of PDAC is characteristically …

The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …

The incidence of noncommunicable diseases (NCDs) has increased over the last few
decades, and one of the major contributors to this is lifestyle, especially diet. High intake of …

The nuclear receptor ligand-binding domain (LBD) is a highly dynamic entity. Crystal
structures have defined multiple low-energy LBD structural conformations of the activation …