Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Spectacular images of neutrophils ejecting nuclear chromatin and bactericidal proteins, in
response to microbes, were first reported in 2004. As externalized chromatin could entangle …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular
and selected cytoplasmic proteins. NETs are released by white blood cells called …

Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high
mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial …

Recent data suggest that NETosis plays a crucial role in the innate immune response and
disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell …

Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Neutrophil extracellular traps (NETs) were discovered as extracellular strands of
decondensed DNA in complex with histones and granule proteins, which were expelled …