The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Hormone-related cancers, namely breast, endometrium, ovary, prostate, testis, thyroid and
osteosarcoma, share a unique mechanism of carcinogenesis. Endogenous and exogenous …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

T is now well accepted that serum testosterone (T) levels decline progressively with aging in
men (1–5). This decline is associated with alterations in body composition; diminished …

Blood samples are an excellent source of large amounts of genomic DNA. However,
alternative sources are often needed in epidemiological studies because of difficulties in …

Carcinoma of the prostate is the most frequently diagnosed malignancy and the second
leading cause of death as a result of cancer in men in the United States and in many other …

This new edition of a highly acclaimed standard reference has been restructured for greater
practical usefulness, to follow the clinical setting: it meticulously describes and illustrates all …

The length of the polymorphic CAG trinucleotide repeat in the polyglutamine region of the
androgen receptor (AR) gene is inversely correlated with the transactivation function of the …

The androgen-androgen receptor (AR) signaling pathway plays a key role in proper
development and function of male reproductive organs, such as prostate and epididymis, as …

The action of androgens is essential for the development of benign prostatic hyperplasia
and carcinoma of the prostate. The androgen receptor is a ligand-dependent nuclear …