The immune checkpoint cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is an
inhibitory regulator of T-cell mediated responses that has been investigated as target of …

Immunotherapies, especially the programmed cell death 1/programmed cell death ligand 1
(PD-1/PD-L1) inhibitors, have revolutionized the therapeutic strategies of various cancers …

Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …

Background Current knowledge on prognostic biomarkers (especially BRAF V600E/RAS
mutations) in metastatic colorectal cancer (mCRC) is mainly based on mCRC patients with …

Therapy with immune checkpoint inhibitors (ICI) is effective in patients with metastatic
mismatch‐repair deficient (dMMR) colorectal cancer (CRC); however, data on treatment with …

Background Because adverse reactions or drug resistance are often found after current
chemotherapies for metastatic colorectal cancer (mCRC), new treatments are still in …

The systemic therapy management of metastatic colorectal cancer (mCRC) has evolved
from primarily cytotoxic chemotherapies to now include targeted agents given alone or in …

Abstract Background Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of
advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been …

(1) Background: colorectal cancer (CRC) is one of the deadliest causes of death by cancer
worldwide. Its first main metastatic diffusion spreads to the liver. Different mechanisms such …

Ethnopharmacological relevance Saffron is one of the traditional medicinal herbs, which
contains various active ingredients, such as safranal, crocin, saffron acid, etc. It has anti …