Emerging roles of nucleotide metabolism in cancer
Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA
synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the …
synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the …
An overview on lipid droplets accumulation as novel target for acute myeloid leukemia therapy
C Nisticò, E Chiarella - Biomedicines, 2023 - mdpi.com
Metabolic reprogramming is a key alteration in tumorigenesis. In cancer cells, changes in
metabolic fluxes are required to cope with large demands on ATP, NADPH, and NADH, as …
metabolic fluxes are required to cope with large demands on ATP, NADPH, and NADH, as …
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Control of cellular identity requires coordination of developmental programs with
environmental factors such as nutrient availability, suggesting that perturbing metabolism …
environmental factors such as nutrient availability, suggesting that perturbing metabolism …
LSD1 inhibition modulates transcription factor networks in myeloid malignancies
Acute Myeloid Leukemia (AML) is a type of cancer of the blood system that is characterized
by an accumulation of immature hematopoietic cells in the bone marrow and blood. Its …
by an accumulation of immature hematopoietic cells in the bone marrow and blood. Its …