Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects

MM El-Mas, AA Abdel-Rahman - … to Human Health and Precision Medicine, 2019 - Springer
Several review articles have been published on the neurobehavioral actions of
acetaldehyde and other ethanol metabolites as well as in major alcohol-related disorders …

Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats

MM El-Mas, J Zhang… - Journal of Applied …, 2006 - journals.physiology.org
Previous reports from our laboratory have shown that ethanol elicits hypotension in female
but not in male rats and that this effect of ethanol is estrogen dependent (El-Mass MM and …

Novel strategies and targets for the management of hypertension

DA Taylor, AA Abdel-Rahman - Advances in Pharmacology, 2009 - Elsevier
Hypertension, as the sole or comorbid component of a constellation of disorders of the
cardiovascular (CV) system, is present in over 90% of all patients with CV disease and …

Nongenomic effects of estrogen mediate the dose-related myocardial oxidative stress and dysfunction caused by acute ethanol in female rats

MM El-Mas, AA Abdel-Rahman - American Journal of …, 2014 - journals.physiology.org
Acute ethanol lowers blood pressure (BP) and cardiac output in proestrus and after chronic
estrogen (E2) replacement in ovariectomized (OVX) female rats. However, whether rapid …

Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats

MM El-Mas, AA Abdel-Rahman - Toxicology and applied pharmacology, 2015 - Elsevier
Evidence suggests that male rats are protected against the hypotensive and myocardial
depressant effects of ethanol compared with females. We investigated whether E 2 modifies …

Longitudinal assessment of the effects of oestrogen on blood pressure and cardiovascular autonomic activity in female rats

MM El‐Mas, AA Abdel‐Rahman - Clinical and Experimental …, 2009 - Wiley Online Library
Summary 1 Published data concerning the effects of ovarian hormones on haemodynamic
variability are contradictory. For the first time, the present study used radiotelemetric …

Estrogen dependence of the renal vasodilatory effect of nicotine in rats: role of α7 nicotinic cholinergic receptor/eNOS signaling

MM El-Mas, SM El-Gowilly, EY Gohar, ARM Ghazal… - Life sciences, 2011 - Elsevier
AIMS: We recently reported that acute exposure to nicotine vasodilates the renal vasculature
of male rats via facilitation of endothelial nitric oxide synthase (eNOS). In this study, we …

Intermittent clonidine regimen abolishes tolerance to its antihypertensive effect: a spectral study

MM El-Mas, AA Abdel-Rahman - Journal of cardiovascular …, 2007 - journals.lww.com
The development of tolerance to the antihypertensive effect of clonidine and related
imidazolines is clinically recognized. Here, we employed a restricted daytime (8: 30 AM until …

Ovariectomy provokes inflammatory and cardiovascular effects of endotoxemia in rats: Dissimilar benefits of hormonal supplements

MA El-Lakany, MA Fouda, HM El-Gowelli… - Toxicology and applied …, 2020 - Elsevier
The female gender is protected against immunological complications of endotoxemia. Here
we investigated whether gonadal hormone depletion by ovariectomy (OVX) uncovers …

Longitudinal studies on the effect of hypertension on circadian hemodynamic and autonomic rhythms in telemetered rats

MM El-Mas, AA Abdel-Rahman - Life Sciences, 2005 - Elsevier
This study dealt with the long-term effects of hypertension on circadian rhythms of
hemodynamic and cardiovascular autonomic functions in radiotelemetered rats. Blood …