Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying …

A Cabrera‐Pastor, M Llansola, C Montoliu… - Acta …, 2019 - Wiley Online Library
Several million patients with liver cirrhosis suffer minimal hepatic encephalopathy (MHE),
with mild cognitive and coordination impairments that reduce their quality of life and life …

2021 ISHEN guidelines on animal models of hepatic encephalopathy

S DeMorrow, C Cudalbu, N Davies… - Liver …, 2021 - Wiley Online Library
This working group of the International Society of Hepatic Encephalopathy and Nitrogen
Metabolism (ISHEN) was commissioned to summarize and update current efforts in the …

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction …

HMA Khalil, HA Eliwa, RA El-Shiekh… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Ashwagandha (ASH) is one of the medicinal plants used
in traditional Indian, Ayurvedic, and Unani medicines for their broad range of …

[HTML][HTML] The neurogliovascular unit in hepatic encephalopathy

W Claeys, L Van Hoecke, S Lefere, A Geerts… - JHEP reports, 2021 - Elsevier
Hepatic encephalopathy (HE) is a neurological complication of hepatic dysfunction and
portosystemic shunting. It is highly prevalent in patients with cirrhosis and is associated with …

Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study

A Sepehrinezhad, A Shahbazi, MT Joghataei… - Cell death & …, 2023 - nature.com
There is accumulating evidence that the circulatory levels of autotaxin (ATX) and
lysophosphatidic acid (LPA) are increased in patients with severe liver disease. However …

The glymphatic system may play a vital role in the pathogenesis of hepatic encephalopathy: a narrative review

A Sepehrinezhad, F Stolze Larsen… - Cells, 2023 - mdpi.com
Hepatic encephalopathy (HE) is a neurological complication of liver disease resulting in
cognitive, psychiatric, and motor symptoms. Although hyperammonemia is a key factor in the …

Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema

A Sepehrinezhad, A Zarifkar, G Namvar… - Metabolic brain …, 2020 - Springer
Hepatic encephalopathy (HE) may occur in patients with liver failure. The most critical
pathophysiologic mechanism of HE is cerebral edema following systemic hyperammonemia …

[HTML][HTML] Drug-induced-acute liver failure: A critical appraisal of the thioacetamide model for the study of hepatic encephalopathy

A Sepehrinezhad, A Shahbazi, SS Negah… - Toxicology reports, 2021 - Elsevier
Hepatic encephalopathy (HE) following acute and chronic liver failure is defined as a
complex of neuropsychiatric abnormalities, such as discrete personal changes, sleep …

Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via …

SA Ali, AK Datusalia - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Tinospora cordifolia (TC) a potential medicinal herb, has
been ethnobotanically used as an eco-friendly supplement to manage various diseases …

Faecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy

Y Wang, Y Li, L Lv, L Zhu, L Hong, X Wang… - npj Biofilms and …, 2024 - nature.com
Both gut microbiome and microRNAs (miRNAs) play a role in the development of hepatic
encephalopathy (HE). However, the functional link between the microbiome and host …