Hox genes code for transcription factors and are evolutionarily conserved. They regulate a
plethora of downstream targets to define the anterior-posterior (AP) body axis of a …

After nearly 30 years of effort, Ed Lewis published his 1978 landmark paper in which he
described the analysis of a series of mutations that affect the identity of the segments that …

Drosophila bithorax complex (BX-C) is one of the best model systems for studying the role of
boundaries (insulators) in gene regulation. Expression of three homeotic genes, Ubx, abd-A …

The autonomy of segment-specific regulatory domains in the Bithorax complex is conferred
by boundary elements and associated Polycomb response elements (PREs). The Fab-6 …

Expression of Abdominal-B (Abd-B) in abdominal segments A5–A8 is controlled by four
regulatory domains, iab-5–iab-8. Each domain has an initiator element (which sets the …

Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in
the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations …

The homeotic genes or Hox define the anterior–posterior (AP) body axis formation in
bilaterians and are often present on the chromosome in an order collinear to their function …

The Drosophila PAX6 homolog twin of eyeless (toy) sits at the pinnacle of the genetic
pathway controlling eye development, the retinal determination network. Expression of toy in …

Homeodomain transcription factors (TFs) bind to specific DNA sequences to regulate the
expression of target genes. Structural work has provided insight into molecular identities and …

In Drosophila, the 330 kb bithorax complex regulates cellular differentiation along the
anterior–posterior axis during development in the thorax and abdomen and is comprised of …