Most abundant in the extracellular matrix are collagens, joined by elastin that confers elastic
recoil to the lung, aorta, and skin. These fibrils are highly resistant to proteolysis but can …

Matrix metalloproteinases (MMPs) are zinc-dependent protein and peptide hydrolases. They
have been almost exclusively studied in vertebrates and 23 paralogs are present in humans …

We analysed the roles and distribution of metal ions in enzymatic catalysis using available
public databases and our new resource Metal-MACiE (http://www. ebi. ac. uk/thornton …

Akkermansia muciniphila is a mucin-degrading bacterium commonly found in the human gut
that promotes a beneficial effect on health, likely based on the regulation of mucus thickness …

Bacterial collagenases are metalloproteinases involved in the degradation of the
extracellular matrices of animal cells, due to their ability to digest native collagen. These …

Cancer contributes to 50% of deaths worldwide and new anti-tumour therapeutics with novel
mechanisms of actions are essential to develop. Metabolic inhibitors represent an important …

The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These
ubiquitous enzymes participate in all major physiological processes, and so their …

The zinc-dependent matrix metalloproteinases (MMPs) belong to a large family of
structurally homologous enzymes. These enzymes are involved in a wide variety of …

Human matrix metalloproteinase 9 (MMP-9), also called gelatinase B, is particularly involved
in inflammatory processes, bone remodelling and wound healing, but is also implicated in …

The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of
molecules by bio-inspired metal-based catalysts (metallohydrolases) is required in a wide …