Since COVID‐19 took a strong hold around the globe causing considerable morbidity and
mortality, a lot of effort was dedicated to manufacturing effective vaccines against SARS …

Heparin-induced thrombocytopenia (HIT) is a potentially devastating immune mediated
adverse drug reaction caused by the emergence of antibodies that activate platelets in the …

Anticoagulants are recommended for the prevention and treatment of a wide variety of
thromboembolic events. Although existing anticoagulants are effective, their use is limited by …

When the patent of a small molecule drug expires generics may be introduced. They are
considered therapeutically equivalent once pharmaceutical equivalence (ie identical active …

Thrombocytopenia following heparin administration can be associated with an immune
reaction, now referred to as heparin-induced thrombocytopenia. HIT is essentially a …

Heparin-induced thrombocytopenia (HIT) is a life-threatening, immune-mediated
complication following heparin exposure and is considered to be the most severe adverse …

Background Platelet endothelial aggregation receptor 1 (PEAR1) is a single-transmembrane
orphan receptor primarily expressed on platelets and endothelial cells. Genetic variants of …

Objectives: Review the etiology of thrombocytopenia. Explain the appropriate history,
physical, associated laboratory values, and evaluation of thrombocytopenia. Summarize the …

Deep vein thrombosis (DVT) is a common clinical peripheral vascular disease that occurs
frequently in orthopaedic patients and may lead to pulmonary embolism (PE) if the thrombus …

Rivaroxaban is an oral, direct activated Factor Xa (FXa) inhibitor in advanced clinical
development for the prevention and treatment of thromboembolic disorders. Currently …