Our limited understanding of metabolic aging poses major challenges to comprehending the
diverse cellular alterations that contribute to age-related decline, and to devising targeted …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

The synovium, a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,
undergoes changes in aging that contribute to intense shoulder pain and other joint …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

Dysfunction of the ribosome manifests during cellular senescence and contributes to tissue
aging, functional decline, and development of aging-related disorders in ways that have …

Although mitochondrial aldehyde dehydrogenase 2 (ALDH2) is involved in aging and aging-
related diseases, its role in the regulation of human mesenchymal stem cell (MSC) …

Nucleosome assembly proteins (NAPs) have been identified as histone chaperons. Testis‐
Specific Protein, Y‐Encoded‐Like (TSPYL) is a newly arisen NAP family in mammals …