As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of
glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. Uptake …

Abstract Background Tumour-associated macrophages (TAMs) in the tumour
microenvironment (TME) can promote the progression of hepatocellular carcinoma (HCC) …

Eukaryotic cell division is known to be controlled by the cyclin/cyclin dependent kinase
(CDK) machinery. However, eukaryotes have evolved prior to CDKs, and cells can divide in …

mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to
promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle …

Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover.
Limiting the supply of macromolecular precursors by targeting enzymes involved in …

Phosphatidic acid (PA) is a critical metabolite at the heart of membrane phospholipid
biosynthesis. However, PA also serves as a critical lipid second messenger that regulates …

Cell division involves a series of ordered and controlled events that lead to cell proliferation.
Cell cycle progression implies not only demanding amounts of cell mass, protein, lipid, and …

Glutamine is one of the main nutrients used by tumor cells for biosynthesis. Therefore,
targeted inhibition of glutamine metabolism may have anti-tumorigenic implications. In the …