Application and synthesis of thiazole ring in clinically approved drugs

ZX Niu, YT Wang, SN Zhang, Y Li, XB Chen… - European Journal of …, 2023 - Elsevier
The development of heterocyclic derivatives has progressed considerably over the past few
decades, and many new agents of synthetic and natural origin have been produced. Among …

Thiazole ring—A biologically active scaffold

A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Thiazole compounds as antiviral agents: An update

IP Singh, S Gupta, S Kumar - Medicinal Chemistry, 2020 - ingentaconnect.com
Background: Thiazole is a good nucleus owing to its various pharmaceutical applications.
Thiazole containing compounds (thiazoles) have shown various biological activities like …

New heterocyclic hybrids of pyrazole and its bioisosteres: Design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents

AA Bekhit, AMM Hassan, HA Abd El Razik… - European journal of …, 2015 - Elsevier
A new series of pyrazole derivatives were synthesized by hybridization with five-membered
heterocyclic moieties such as thiazoles, thiazolidinones, 1, 3, 4-thiadiazoles and …

Synthesis and biological evaluation of coumarin appended thiazole hybrid heterocycles: Antibacterial and antifungal study

NV Sadgir, VA Adole, SL Dhonnar… - Journal of Molecular …, 2023 - Elsevier
In the present investigation, a series of 3-(1-(2-(thiazol-2-yl) hydrazineylidene) ethyl)-2H-
chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a …

Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis …

Y Wang, C Wu, Q Zhang, Y Shan, W Gu, S Wang - Bioorganic chemistry, 2019 - Elsevier
A series of novel β-pinene-based thiazole derivatives were synthesized and characterized
by HRMS, 1 H NMR, and 13 C NMR analyses as potential antineoplastic agents. Derivatives …

In vitro and in silico antimalarial activity of 2-(2-hydrazinyl) thiazole derivatives

P Makam, PK Thakur, T Kannan - European Journal of Pharmaceutical …, 2014 - Elsevier
Abstract A series of 2-(2-hydrazinyl) thiazole derivatives with a wide range of substitutions at
2-, 4-and 5-positions were synthesized, characterized and evaluated their inhibitory …

Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA …

MG Kamel, FM Sroor, MKH Hanafy, KF Mahrous… - RSC …, 2024 - pubs.rsc.org
Less than 5% of pancreatic cancer patients survive for more than five years after diagnosis.
Therefore, there is an urgent need for novel therapeutic drugs to treat pancreatic cancer …

Synthesis, spectral, antifungal, in silico molecular docking, ADME and DFT studies of some 2-(2-hydrazineyl) thiazole derivatives: Computational and experimental …

SL Dhonnar, VA Adole, RH Patil, BB Khairnar… - Journal of Molecular …, 2023 - Elsevier
A series of thiazole Schiff bases (4a-4q) is synthesized and evaluated for the antibiofilm
potential against fungal species C. albicans. The compounds 4a, 4b, 4c, 4p and 4q showed …

Antifungal activity, SAR and physicochemical correlation of some thiazole-1, 3, 5-triazine derivatives

UP Singh, HR Bhat, P Gahtori - Journal de mycologie médicale, 2012 - Elsevier
OBJECTIVE: Present research communication was towards the investigation of antifungal
minimum inhibitory concentration (MIC) and minimum fingicidal concentration (MFC) activity …