A survey of the mechanisms of action of anticancer transition metal complexes

M Marloye, G Berger, M Gelbcke… - Future medicinal …, 2016 - Taylor & Francis
Metal complexes have been the subject of numerous investigations in oncology but, despite
the plethora of newly synthesized compounds, their precise mechanisms of action remain …

Recent advancements in coordination compounds and their potential clinical application in the management of diseases: An up-to-date review

VK Singh, VK Singh, A Mishra, AA Singh, G Prasad… - Polyhedron, 2023 - Elsevier
Coordination compounds-based drugs are crucial in targeting various diseases due to their
distinct structural order. They also show a significant role in biological systems, including …

Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents

AR Fernandes, J Jesus, P Martins, S Figueiredo… - Journal of Controlled …, 2017 - Elsevier
Due to their small size and unique properties, multifunctional nanoparticles arise as versatile
delivery systems easily grafted with a vast array of functional moieties, such as anticancer …

Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells

P Pedrosa, R Mendes, R Cabral, LM Martins… - Scientific Reports, 2018 - nature.com
Despite great advances in the fight against cancer, traditional chemotherapy has been
hindered by the dose dependent adverse side effects that reduce the usable doses for …

Synthesis, characterization, thermal properties and antiproliferative potential of copper (II) 4′-phenyl-terpyridine compounds

Z Ma, B Zhang, MFCG Da Silva, J Silva… - Dalton …, 2016 - pubs.rsc.org
Reactions between 4′-phenyl-terpyridine (L) and several Cu (II) salts (p-toluenesulfonate,
benzoate and o-, m-or p-hydroxybenzoate) led to the formation of [Cu (p-SO3C6H4CH3) L …

Heteroleptic mononuclear compounds of ruthenium (II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

OA Lenis-Rojas, AR Fernandes… - Dalton …, 2016 - pubs.rsc.org
The limitations of platinum complexes in cancer treatment have motivated the extensive
investigation into other metal complexes such as ruthenium. We herein present the …

Human and bovine serum albumin time-resolved fluorescence: tryptophan and tyrosine contributions, effect of DMSO and rotational diffusion

R Starosta, FC Santos, RFM de Almeida - Journal of Molecular Structure, 2020 - Elsevier
Albumin is the most abundant protein in mammalian serum and one of the major natural
drug carriers in human body, therefore the study of small molecule interactions and other …

Gold nanoparticles for BCR-ABL1 gene silencing: improving tyrosine kinase inhibitor efficacy in chronic myeloid leukemia

R Vinhas, AR Fernandes, PV Baptista - Molecular Therapy-Nucleic Acids, 2017 - cell.com
Introduction of tyrosine kinase inhibitors for chronic myeloid leukemia treatment is
associated with a 63% probability of maintaining a complete cytogenetic response, meaning …

Cu (I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of …

D Sequeira, PV Baptista, R Valente… - Dalton …, 2021 - pubs.rsc.org
Cancer is one of the worst health issues worldwide, representing the second leading cause
of death. Current chemotherapeutic drugs face some challenges like the acquired resistance …

Improving the anti-inflammatory response via gold nanoparticle vectorization of CO-releasing molecules

AR Fernandes, I Mendonça-Martins… - ACS Biomaterials …, 2020 - ACS Publications
CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory,
antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal …