Enoyl acyl carrier protein reductase inhibitors: An updated patent review (2011–2015)
ABSTRACT Introduction: Enoyl-(acyl-carrier-protein) reductase (ENR) is a limiting step
enzyme in the Fatty Acid Synthase II system. In mammals, there is no homologue to ENR …
enzyme in the Fatty Acid Synthase II system. In mammals, there is no homologue to ENR …
Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum
JK O'Hara, LJ Kerwin, SA Cobbold, J Tai, TA Bedell… - PLoS …, 2014 - journals.plos.org
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox
cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have …
cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have …
Hemoglobin degrading proteases of Plasmodium falciparum as antimalarial drug targets
T Qidwai - Current drug targets, 2015 - ingentaconnect.com
Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases
involved in human host hemoglobin degradation and other processes like erythrocyte …
involved in human host hemoglobin degradation and other processes like erythrocyte …
Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents
FC Schrader, S Glinca, JM Sattler, HM Dahse… - …, 2013 - Wiley Online Library
Malaria is a potentially fatal disease caused by Plasmodium parasites and poses a major
medical risk in large parts of the world. The development of new, affordable antimalarial …
medical risk in large parts of the world. The development of new, affordable antimalarial …
[HTML][HTML] Pravastatin and simvastatin inhibit the adhesion, replication and proliferation of Toxoplasma gondii (RH strain) in HeLa cells
RA Sanfelice, SS da Silva, LR Bosqui… - Acta tropica, 2017 - Elsevier
The conventional treatment for toxoplasmosis with pyrimethamine and sulfadiazine shows
toxic effects to the host, and it is therefore necessary to search for new drugs. Some studies …
toxic effects to the host, and it is therefore necessary to search for new drugs. Some studies …
Conformational Stability and Thermal Pathways of Relaxation in Triclosan (Antibacterial/Excipient/Contaminant) in Solid-State: Combined Spectroscopic (1H NMR) …
JN Latosinska, M Latosinska… - The Journal of …, 2015 - ACS Publications
The mechanism of molecular dynamics in the antibacterial/antifungal agent, triclosan (5-
chloro-2-(2′, 4′-dichlorophenoxy)-phenol), in solid state was studied by 1H NMR …
chloro-2-(2′, 4′-dichlorophenoxy)-phenol), in solid state was studied by 1H NMR …
Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase
L Tallorin, JD Durrant, QG Nguyen… - Bioorganic & medicinal …, 2014 - Elsevier
Enoyl-acyl carrier protein reductase (ENR), a critical enzyme in type II fatty acid biosynthesis,
is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In …
is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In …
In vitro and in silico anti-malarial activity and cytotoxicity of n-hexyl 1-O-rutinoside (a glycoside) isolated from Annickia polycarpa (DC.) Setten and Maas ex IM Turner …
Ethnopharmacological relevance Annickia polycarpa leaf is an effective anti-malarial agent.
However, its chemical constituents have not been isolated and assayed against any …
However, its chemical constituents have not been isolated and assayed against any …
In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors
The need for novel therapeutics against Plasmodium falciparum is urgent due to recent
emergence of multi-drug resistant malaria parasites. Since fatty acids are essential for both …
emergence of multi-drug resistant malaria parasites. Since fatty acids are essential for both …
[PDF][PDF] Computational simulations of phytoconstituents derived from Phyllanthus amarus against Plasmodium falciparum molecular targets
A FID, S Ibrahim - Drug Discovery, 2023 - researchgate.net
There has been an increase in the resistance of plasmodium parasites to already available
malaria prevention drugs. Hence, the need for novel malaria-preventive medications. This …
malaria prevention drugs. Hence, the need for novel malaria-preventive medications. This …