It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

The ability of animals to regenerate missing parts is a dramatic and poorly understood
aspect of biology. The sources of new cells for these regenerative phenomena have been …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Forward genetic screens in model organisms have provided important insights into
numerous aspects of development, physiology and pathology. With the availability of …

Commercial biotechnology solutions for controlling lepidopteran and coleopteran insect
pests on crops depend on the expression of Bacillus thuringiensis insecticidal proteins …

A serious shortcoming of many insecticides is that they can kill non-target species. To
address this issue, we harnessed the sequence specificity of RNA interference (RNAi) to …

▪ Abstract The principles underlying regeneration in planarians have been explored for over
100 years through surgical manipulations and cellular observations. Planarian regeneration …

Many metazoan cells can take up exogenous double-stranded (ds) RNA and use it to initiate
an RNA silencing response, however, the mechanism for this uptake is ill-defined. Here, we …

In most eukaryotes, double‐stranded RNA is processed into small RNAs that are potent
regulators of gene expression. This gene silencing process is known as RNA silencing or …

Regeneration requires signaling from a wound site for detection of the wound and a
mechanism that determines the nature of the injury to specify the appropriate regenerative …