Stem cells are unique cell populations with the ability to undergo both self-renewal and
differentiation. A wide variety of adult mammalian tissues harbors stem cells, yet “adult” stem …

This article reviews actual advances in the development and application of three-
dimensional (3-D) cell culture systems. Recent therapeutically oriented studies include …

Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion,
inflammation, vessel injury/repair, wound healing, temperature regulation, digestion …

The mechanisms involved in the regulation of vasculogenesis still remain unclear in
mammals. Totipotent embryonic stem (ES) cells may represent a suitable in vitro model to …

The assembly of the vessel wall from its cellular and extracellular matrix components is a
critical process in the development and maturation of the cardiovascular system. However …

Vascular endothelial–cadherin (VE–cadherin) is exclusively expressed in endothelial cells
and is strictly located at cell-to-cell junctions. As the other members of the cadherin family …

Background—Embryonic stem (ES) cells are distinguished by their capacity for self-renewal
and pluripotency. Here we characterize the differentiation of ES cell–derived endothelial …

The controlled differentiation of mouse embryonic stem (ES) cells into near homogeneous
populations of both neurons and skeletal muscle cells that can survive and function in vivo …

Despite the development of improved therapies and the significant advances in the
understanding of the basis of disease pathogenesis, millions of Americans continue to live …

The molecular mechanisms controlling inductive events leading to the specification and
terminal differentiation of cardiomyocytes are still largely unknown. We have investigated the …