Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
B Lassègue, A San Martín, KK Griendling - Circulation research, 2012 - Am Heart Assoc
atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …
Nox proteins in signal transduction
DI Brown, KK Griendling - Free Radical Biology and Medicine, 2009 - Elsevier
The NADPH oxidase (Nox) family of superoxide (O2−) and hydrogen peroxide (H2O2)-
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
producing proteins has emerged as an important source of reactive oxygen species (ROS) …
Reactive oxygen species and vascular biology: implications in human hypertension
RM Touyz, AM Briones - Hypertension research, 2011 - nature.com
Increased vascular production of reactive oxygen species (ROS; termed oxidative stress)
has been implicated in various chronic diseases, including hypertension. Oxidative stress is …
has been implicated in various chronic diseases, including hypertension. Oxidative stress is …
NADPH oxidases and cancer
K Roy, Y Wu, JL Meitzler, A Juhasz, H Liu… - Clinical …, 2015 - portlandpress.com
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …
remained incompletely understood until the discovery over the last 15 years of the family of …
NADPH oxidases: a perspective on reactive oxygen species production in tumor biology
JL Meitzler, S Antony, Y Wu, A Juhasz… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …
transduction, and an environment that can sustain tumor formation and growth. The NOX …
NOX enzymes as novel targets for drug development
The members of the NOX/DUOX family of NADPH oxidases mediate such physiologic
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …
NOX5 in human spermatozoa: expression, function, and regulation
Physiological and pathological processes in spermatozoa involve the production of reactive
oxygen species (ROS), but the identity of the ROS-producing enzyme system (s) remains a …
oxygen species (ROS), but the identity of the ROS-producing enzyme system (s) remains a …
The NADPH oxidase family and its inhibitors
P Kleniewska, A Piechota, B Skibska… - Archivum immunologiae et …, 2012 - Springer
The classical nicotinamide adenine dinucleotide phosphate (NADPH) oxidase was
originally detected in neutrophils as a multicomponent enzyme that catalyzes the generation …
originally detected in neutrophils as a multicomponent enzyme that catalyzes the generation …
Nox5 and the regulation of cellular function
DJR Fulton - Antioxidants & redox signaling, 2009 - liebertpub.com
The NADPH oxidase (Nox) family of enzymes is comprised of seven members, Noxes 1–5
and the Duoxes 1 and 2. Nox5 was the last of the conventional Nox enzymes to be …
and the Duoxes 1 and 2. Nox5 was the last of the conventional Nox enzymes to be …
Inhibiting the activity of NADPH oxidase in cancer
MM Konaté, S Antony, JH Doroshow - Antioxidants & redox …, 2020 - liebertpub.com
Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …