Colorectal cancer in Iran: molecular epidemiology and screening strategies

R Dolatkhah, MH Somi, MJ Bonyadi… - Journal of cancer …, 2015 - Wiley Online Library
Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in
Iran has made it a major public health burden. This study aimed to report its epidemiologic …

[HTML][HTML] Gut microbiota, epigenetic modification and colorectal cancer

S Rezasoltani, H Asadzadeh-Aghdaei… - Iranian journal of …, 2017 - ncbi.nlm.nih.gov
Micro-organisms contain 90% of cells in human body and trillions foreign genes versus less
than 30 thousand of their own. The human colon host various species of microorganisms …

Low level of microsatellite instability correlates with poor clinical prognosis in stage II colorectal cancer patients

EN Mojarad, SMH Kashfi, H Mirtalebi… - Journal of …, 2016 - Wiley Online Library
The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC)
requires more investigation. We assessed the role of MSI status in survival of individuals …

Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous …

F Ghadamyari, MM Heidari, S Zeinali… - Journal of Clinical …, 2021 - Wiley Online Library
Background Familial adenomatous polyposis (FAP) as a colon cancer predisposition
syndrome is an autosomal‐dominant inherited condition and is diagnosed by the progress …

[HTML][HTML] Prognostic significance of nuclear β-catenin expression in patients with colorectal cancer from Iran

EN Mojarad, SMH Kashfi, H Mirtalebi… - Iranian Red Crescent …, 2015 - ncbi.nlm.nih.gov
Background: Beta catenin plays a key role in cancer tumorigenesis. However, its prognostic
significance in patients with colorectal cancer (CRC) remains controversial. It has been …

[HTML][HTML] Tumor suppressor genes in familial adenomatous polyposis

N Eshghifar, N Farrokhi, T Naji… - … and Hepatology from Bed …, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is mostly due to a series of genetic alterations that are being
greatly under the influence of the environmental factors. These changes, mutational or …

Synonymous mutation adenomatous polyposis coliΔ486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase …

WQ Liu, J Dong, YX Peng… - Molecular Medicine …, 2018 - spandidos-publications.com
Familial adenomatous polyposis (FAP) is an autosomal dominant‑inherited colorectal
cancer. Recent advances in genetics have indicated that the majority of patients with FAP …

An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients

SM Mirabdolhosseini, L Rejali… - … Nucleotides & Nucleic …, 2024 - Taylor & Francis
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal cancer
syndrome that is characterized by the development of multiple adenomas in the colon and …

[HTML][HTML] Cronkhite-Canada syndrome; a case report and review of the literature

MT Safari, S Shahrokh, S Ebadi… - … and Hepatology from …, 2016 - ncbi.nlm.nih.gov
Cronkhite-Canada syndrome (CCS) considered as a rare and non-hereditary disorder.
Gastrointestinal polyposis and diarrhea along with some extra signs and symptoms such as …

New Mutations in APC Gene Among Familial Adenomatous Polyposis (FAP) Patients in Iran

PS Gerdehsang, N Ranji, M Gorji… - … Journal of Human …, 2017 - Taylor & Francis
Familial adenomatous polyposis (FAP) is a disorder by autosomal dominant inheritance
caused by mutations in adenomatous polyposis coli (APC) gene. The aim of this paper was …