The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Conspectus The dynamics of protein binding pockets are crucial for their interaction
specificity. Structural flexibility allows proteins to adapt to their individual molecular binding …

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …

Cholesterol and its relatives possessing the 1, 2-cyclopentanoperhydrophenanthrene ring
system (Figure 1) form the sterolome, which comprises a chemical library of more than 1000 …

One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the
immunocompromised population and causes 600,000 deaths/year. The cytochrome P450 …

Fungal diseases are an increasing global burden. Fungi are now recognised to kill more
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …

Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …