The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

The fundamental role played by neutrophils for an efficient, acute inflammatory response
has long been appreciated, with the underlying molecular and cellular mechanisms largely …

Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

Acute and chronic inflammatory responses in the lung are associated with the accumulation
of large quantities of immune and structural cells undergoing apoptosis, which need to be …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied
over several decades, but was only recently recognized as a key player in mediating …

The incidence of idiopathic pulmonary fibrosis is on the rise and existing treatments have
failed to halt or reverse disease progression. Mesenchymal stromal cells (MSCs) have …

PTX3 is a soluble pattern recognition molecule (PRM) belonging to the humoral innate
immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in …

Abstract Changes in macrophage phenotype have been implicated in apoptotic cell-
mediated immune modulation via induction of peroxisome proliferator-activated receptor-γ …

In healthy individuals, billions of cells die by apoptosis each day. Clearance of these
apoptotic cells, termed “efferocytosis,” must be efficient to prevent secondary necrosis and …

For almost two decades, cell-based therapies have been tested in modern regenerative
medicine to either replace or regenerate human cells, tissues, or organs and restore normal …