BACKGROUND Over the past century, innovations in synthetic chemistry have greatly
enabled the discovery and development of important life-changing medicines, improving the …

Abstract Background The STimulator of INterferon Genes (STING) plays an essential role in
the innate immune system by inducing the expression of type I interferons (IFNs) and …

The introduction of molecular complexity in an atom-and step-efficient manner remains an
outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely …

Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of
type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of …

The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic
acids, by triggering a robust interferon response. Despite the importance of this protein as a …

The innate immune system is an organism's first line of defense against an onslaught of
internal and external threats. The downstream adaptive immune system has been a popular …

Nucleosides, nucleotides, and oligonucleotides modulate diverse cellular processes
ranging from protein production to cell signaling. It is therefore unsurprising that synthetic …

Abstract Treatment of cancer by activation of an antitumor immune response is now a widely
practiced and well-accepted approach to therapy. However, despite dramatic responses in …

Background: Nucleic acid sensing is an essential strategy employed by the innate immune
system to detect both pathogen-derived nucleic acids and self-DNA released by host …

Cyclic nucleotides are important signaling molecules that play many critical physiological
roles including controlling cell fate and development, regulation of metabolic processes, and …