Aberrant activation of the signal transducer and activator of transcription (STAT) 3 occurs in
many human tumors. Constitutive STAT3 activity induces specific target genes that stimulate …

The foreign body response (FBR) comprises a general, ubiquitous host tissue-based
reaction to implanted materials. In vitro cell-based models are frequently employed to study …

Persistent activation of signal transducer and activator of transcription 3 (STAT3) has been
shown to impart several oncogenic features in many solid and blood tumors. In this study …

Abstract Background Spontaneous interleukin-6 (IL-6) production has been observed in
various tumors and implicated in the pathogenesis, progression and drug resistance in …

More and more studies show that signal transducer and activator of transcription 3 (STAT3)
is frequently constitutively activated in a wide number of malignancies and named as an …

Signal transducer and activator of transcription 3 (Stat3) is involved in aberrant growth and
survival signals in malignant tumor cells and is a validated target for anticancer drug design …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a
major role in the development of resistance to conventional anti‐cancer drugs in many types …

OBJECTIVE: Signal transducer and activator of transcription 3 (STAT3) are constitutively
activated in a variety of cancers and it is a common feature of ovarian cancer. Thus, STAT3 …

Osteoarthritis (OA) of the knee is often characterized by joint space narrowing on X-ray, knee
pain, and a loss of joint function through progressive cartilage degradation and intermittent …

One scenario by which tumors escape immune recognition is the constitutive activation of
signal transducer and activator of transcription 3 (STAT3). This transcription factor mediates …