The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The
primary function of gastrulation is the correct placement of precursor tissues for subsequent …

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human
cancers. PTEN germline mutations are found in three related human autosomal dominant …

In multicellular organisms, the ability to regulate reproduction, development, and nutrient
utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that …

Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte
function. Here, we show that transient inhibition of HNF4α initiates hepatocellular …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

The serine/threonine kinase Akt has been implicated in the control of cell survival and
metabolism. Here we report the disruption of the most ubiquitously expressed member of the …

The expansion of GAG triplet repeats in the translated region of the human HD gene,
encoding a protein (huntingtin) of unknown function, is a dominant mutation leading to …

In the mouse, the definitive endoderm is derived from the epiblast during gastrulation, and,
at the early organogenesis stage, forms the primitive gut tube, which gives rise to the …