SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
All coronaviruses known to have recently emerged as human pathogens probably
originated in bats. Here we use a single experimental platform based on immunodeficient …

A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice

SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

R Robinot, M Hubert, GD de Melo, F Lazarini… - Nature …, 2021 - nature.com
Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define
the parameters controlling the severity of COVID-19. Here we examine the functional and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

Y Zheng, MW Zhuang, L Han, J Zhang… - Signal transduction and …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

JJ Feld, C Kandel, MJ Biondi, RA Kozak… - The Lancet …, 2021 - thelancet.com
Background To date, only monoclonal antibodies have been shown to be effective for
outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate …

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

A Rebendenne, AL Chaves Valadão, M Tauziet… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of
coronavirus disease 19 (COVID-19), which ranges from mild respiratory symptoms to acute …

Coinfection with influenza A virus enhances SARS-CoV-2 infectivity

L Bai, Y Zhao, J Dong, S Liang, M Guo, X Liu, X Wang… - Cell research, 2021 - nature.com
The upcoming flu season in the Northern Hemisphere merging with the current COVID-19
pandemic raises a potentially severe threat to public health. Through experimental …