Diagnosis and treatment of bipolar disorder: a review

AA Nierenberg, B Agustini, O Köhler-Forsberg, C Cusin… - JAMA, 2023 - jamanetwork.com
Importance Bipolar disorder affects approximately 8 million adults in the US and
approximately 40 million individuals worldwide. Observations Bipolar disorder is …

Bipolar disorders: an update on critical aspects

V Oliva, G Fico, M De Prisco, X Gonda… - The Lancet Regional …, 2025 - thelancet.com
Bipolar disorders are chronic psychiatric conditions characterized by recurrent episodes of
mania and depression. Affecting over 1% of the global population, these disorders …

Antidepressants and bipolar disorder: the plot thickens

N Gottlieb, AH Young - American Journal of Psychiatry, 2024 - psychiatryonline.org
The most appropriate use of antidepressants for bipolar depression is still debated. There is
conflicting evidence for their efficacy, both as adjunctive therapy (3–6) and as monotherapy …

Outpatient Management of Bipolar Disorder in Older Adults

BE Donley, EC Garcia-Pittman - Current Psychiatry Reports, 2024 - Springer
Outpatient clinicians treating OABD should take an active role in the recognition and
management of medical comorbidities. A careful history and examination might reveal subtle …

Prior psychiatric morbidity and differential psychopharmacological treatment patterns: Exploring the heterogeneity of bipolar disorder in a nationwide study of 9594 …

A Ratheesh, M Speed, E Salagre, M Berk… - Bipolar …, 2024 - Wiley Online Library
Objectives Individuals with bipolar disorders (BD) have heterogenic pre‐onset illness
courses and responses to treatment. The pattern of illness preceding the diagnosis of BD …

Adjunctive antidepressants for the treatment of bipolar depression: An updated meta-analysis of randomized clinical trials

A Shafiee, H Moltazemi, MJ Amini, OK Gargari… - Asian Journal of …, 2024 - Elsevier
This updated meta-analysis aims to evaluate the efficacy of adjunctive antidepressants in
the treatment of bipolar depression. The antidepressant group exhibited a significant …

Mood regulation in euthymic patients with a history of antidepressant‐induced mania

R Halabi, K Yusuff, C Park, A DeShaw… - Bipolar …, 2024 - Wiley Online Library
Introduction The use of antidepressants in bipolar disorder (BD) remains contentious, in part
due to the risk of antidepressant‐induced mania (AIM). However, there is no information on …

[HTML][HTML] Facilitating microglia M2 polarization alleviates p-Synephrine-induced depressive-like behaviours in CSDS mice via the 5-HT6R-FYN-ERK1/2 pathway

S Wang, Q Li, D Deng, Z Xie, K Cao, F Zhang… - International …, 2025 - Elsevier
In recent years, modulation of microglial phenotype transformation has emerged as a
promising strategy for treating central nervous system disorders. Aurantii Fructus Immaturus …

Exploring real-world prescribing patterns for maintenance treatment in bipolar disorders: a focus on antidepressants and benzodiazepines

S Andric Petrovic, D Jankovic, N Kaurin… - … Journal of Psychiatry …, 2024 - Taylor & Francis
Objective Bipolar disorders (BD) are characterized by highly recurrent nature, necessitating
adequate maintenance treatment for long-term disorder control. This study aimed to …

Concept article: Antidepressant‐induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3)

IH Aydin, RS El‐Mallakh - Bipolar Disorders, 2024 - Wiley Online Library
Objectives Antidepressants used by patients with bipolar disorder have been associated
with destabilization with an increase in mania, depression, and cycling. The most commonly …