Cardiovascular disease is a leading cause of mortality in the world and is exacerbated by
the presence of cardiac fibrosis, defined by the accumulation of noncontractile extracellular …

Context Stem cell therapy is rapidly developing and has generated excitement and promise
as well as confusion and at times contradictory results in the lay and scientific literature …

Aims Comparison of intracoronary infusion of bone marrow (BM)-derived unselected
mononuclear cells (UNSEL) and selected CD34+ CXCR4+ cells (SEL) in patients with acute …

Randomized, controlled clinical trials have demonstrated that cell therapy can improve the
recovery of cardiac function in patients after acute myocardial infarction (AMI). Trial results …

Cell-based therapy is a promising option for treatment of ischemic diseases. Several cell
types have experimentally been shown to increase the functional recovery of the heart after …

Aims Stem cell therapy is a treatment strategy for ischaemic heart disease patients. Meta-
analysis of randomized human trials showed< 5% improvement in left ventricular ejection …

The heart is a complex organ system composed of a highly diverse set of muscle and
nonmuscle cells. Understanding the pathways that drive the formation, migration, and …

Introduction Stem cell therapy has emerged as a promising strategy for the treatment of
ischemic cardiomyopathy. Sources of data Multiple candidate cell types have been used in …

Myocardial infarction irreversibly destroys millions of cardiomyocytes in the ventricle, making
it the leading cause of heart failure worldwide. Over the past two decades, many progenitor …

Cell-based therapy is a promising option for treatment of cardiovascular diseases. Based on
experimental studies demonstrating that bone marrow-derived stem and progenitor cells …