Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Graphene sensor arrays for rapid and accurate detection of pancreatic cancer exosomes in patients' blood plasma samples

T Yin, L Xu, B Gil, N Merali, MS Sokolikova… - ACS …, 2023 - ACS Publications
Biosensors based on graphene field effect transistors (GFETs) have the potential to enable
the development of point-of-care diagnostic tools for early stage disease detection …

Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis

Y Lee, J Ni, J Beretov, VC Wasinger, P Graham, Y Li - Molecular cancer, 2023 - Springer
Current clinical tools for breast cancer (BC) diagnosis are insufficient but liquid biopsy of
different bodily fluids has recently emerged as a minimally invasive strategy that provides a …

Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives

P Pattanayak, SK Singh, M Gulati, S Vishwas… - Microfluidics and …, 2021 - Springer
Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …

Computer vision-based artificial intelligence-mediated encoding-decoding for multiplexed microfluidic digital immunoassay

W Zhao, Y Zhou, YZ Feng, X Niu, Y Zhao, J Zhao… - ACS …, 2023 - ACS Publications
Digital immunoassays with multiplexed capacity, ultrahigh sensitivity, and broad affordability
are urgently required in clinical diagnosis, food safety, and environmental monitoring. In this …

Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact

JD Spitzberg, S Ferguson, KS Yang… - Nature …, 2023 - nature.com
Exosomes and extracellular vesicles (EV) are increasingly being explored as circulating
biomarkers, but their heterogenous composition will likely mandate the development of …

Towards microfluidic-based exosome isolation and detection for tumor therapy

J Wang, P Ma, DH Kim, BF Liu, U Demirci - Nano Today, 2021 - Elsevier
Exosomes are a class of cell-secreted, nano-sized extracellular vesicles with a bilayer
membrane structure of 30–150 nm in diameter. Their discovery and application have …

Future of digital assays to resolve clinical heterogeneity of single extracellular vesicles

RTT Morales, J Ko - ACS nano, 2022 - ACS Publications
Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Progress in microfluidics‐based exosome separation and detection technologies for diagnostic applications

S Lin, Z Yu, D Chen, Z Wang, J Miao, Q Li, D Zhang… - Small, 2020 - Wiley Online Library
Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have
revealed that exosomes play a significant role in intercellular communication and are closely …