Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Background The role of tumor necrosis factor alpha (TNF-α) in targeted therapy for
hepatocellular carcinoma (HCC) remains largely unknown. The current study aimed to …

Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity
that plays pleiotropic roles in health and disease. It is involved in several physiological …

Cyclophosphamide is indicated for the treatment of cancerous diseases such as breast
cancer and cervical cancer. Recent studies have shown that cyclophosphamide may induce …

During chemotherapy, drug resistance caused by autophagy remains a major challenge to
successful treatment of cancer patients. The purpose of this study is to show that ulinastatin …

Objective To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer
cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells …

Distant metastasis is the primary reason for treatment failure in patients with nasopharyngeal
carcinoma (NPC). In this study, we investigated the effect of ulinastatin (UTI) on NPC …

Matrix metalloproteinases (MMPs) are known to participate in cancer invasion and
metastasis. Copious research on MMPs and their inhibitors has promoted the understanding …

Objective This study aims to investigate the in vitro effects of Ulinastatin (UTI) and Taxotere
(TXT) on cell proliferation; cell apoptosis; xenografted tumor growth; and expression of …

Ulinastatin is a broad-spectrum enzyme inhibitor extracted from urine. Previous data from
our group suggested that ulinastatin could significantly inhibit proliferation of human breast …