The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

Envelope glycoproteins (Env) of lentiviruses typically possess unusually long cytoplasmic
domains, often 150 amino acids or longer. It is becoming increasingly clear that these …

Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission,
systemic infection is typically established by a limited number of founder viruses. Elucidation …

Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in
infection that may be favored at transmission, as well as patterns of recurrent mutation in …

The human immunodeficiency virus type 1 (HIV-1) has been intensely investigated since its
discovery in 1983 as the cause of acquired immune deficiency syndrome (AIDS). With …

We investigated the hypothesis that the correlation between the class I HLA types of an
individual and whether that individual spontaneously controls HIV-1 is mediated by the …

Truncation of the human immunodeficiency virus (HIV) or simian immunodeficiency virus
(SIV) gp41 cytoplasmic tail (CT) can modulate the fusogenicity of the envelope glycoprotein …

The human immunodeficiency virus type 1 (HIV-1) envelope comprises a surface gp120 and
a transmembrane gp41. The cytoplasmic domain of gp41 contains cysteine residues (C764 …

Phospholipase A 2 toxins present in snake venoms interact with biological membranes and
serve as structural models for the design of small peptides with anticancer, antibacterial and …

We report the molecular identification, cloning and initial biological characterization of 12 full-
length HIV-1 subtype A, D and A/D recombinant transmitted/founder (T/F) genomes. T/F …